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Captain Underpants' Brain Cells are neurons belonging to Captain Underpants. They only appear in "The Taxing Trauma of the Treacherous Tattle Trials Part 2".


When George Beard, Harold Hutchins, Melvin Sneedly, and Melvinborg travel through Captain Underpants' brain to get rid of the Nanobots located there, all the brain cells there team up to stop them.