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The Advancimals is a fictional TV show seen in The Epic Tales of Captain Underpants introduced in "The Preposterous Pulverizing of the Pestering Poopacabra." Not much is known about it, but the characters are smart anthropomorphic animals that save the world from villains, just like Captain Underpants. except he isn't an animal. The show first appears in "The Preposterous Pulverizing of the Pestering Poopacabra." where Melvinborg uses it as the name for a class animal-training project.

In "The Angry Abnormal Atrocities of the Astute Animal Aggressors" George and Harold used Beast Booster 2000 to turn a random raccoon, snake and water buffalo into the real versions of the Advancimals to combat the rogue Ragely J. Snarlingtooth and his animals. After Ragely changes, the Advancimals would go with them to build an advanced civilization in the forest. In "The Polarizing Plight of the Pitiless Poopetrators", it is shown that the Advancimals have a live stage show similar to Spider-Man: Turn off the Dark.

It was later on revealed it was canceled in The Heartbreaking Havoc of the Haunting Hack-A-Ween due to poor ratings.

It would later on be revealed in The Interactive Insanity of the Irritating Interlopers where it was rebooted. In this reboot, it is revealed that the Advancimals gained their intellect via an artifact known as the 'Advancicrystal'.